If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 1 Sep 1910 | Tottenham Hotspur | H | W | 2-0 | (2-0) | First Division | D1 |
| 3 Sep 1910 | Middlesbrough | A | L | 0-1 | (0-0) | First Division | D1 |
| 10 Sep 1910 | Preston North End | H | W | 2-0 | (0-0) | First Division | D1 |
| 17 Sep 1910 | Notts County | A | D | 0-0 | (0-0) | First Division | D1 |
| 24 Sep 1910 | Manchester United | H | L | 0-1 | (0-0) | First Division | D1 |
| 1 Oct 1910 | Liverpool | A | W | 2-0 | (2-0) | First Division | D1 |
| 8 Oct 1910 | Bury | H | W | 2-1 | (0-0) | First Division | D1 |
| 15 Oct 1910 | Sheffield United | A | W | 1-0 | (1-0) | First Division | D1 |
| 22 Oct 1910 | Aston Villa | H | L | 0-1 | (0-0) | First Division | D1 |
| 29 Oct 1910 | Sunderland | A | L | 0-4 | (0-3) | First Division | D1 |
| 5 Nov 1910 | Woolwich Arsenal | H | W | 2-0 | (2-0) | First Division | D1 |
| 12 Nov 1910 | Bradford City | A | L | 1-3 | (1-1) | First Division | D1 |
| 19 Nov 1910 | Blackburn Rovers | H | W | 6-1 | (0-0) | First Division | D1 |
| 26 Nov 1910 | Nottingham Forest | A | D | 1-1 | (0-1) | First Division | D1 |
| 3 Dec 1910 | Manchester City | H | W | 1-0 | (1-0) | First Division | D1 |
| 10 Dec 1910 | Oldham Athletic | H | W | 1-0 | (1-0) | First Division | D1 |
| 17 Dec 1910 | The Wednesday | A | W | 2-0 | (0-0) | First Division | D1 |
| 24 Dec 1910 | Bristol City | H | W | 4-3 | (1-1) | First Division | D1 |
| 26 Dec 1910 | Newcastle United | A | L | 0-1 | (0-1) | First Division | D1 |
| 27 Dec 1910 | Liverpool | H | L | 0-1 | (0-0) | First Division | D1 |
| 31 Dec 1910 | Middlesbrough | H | W | 2-0 | (1-0) | First Division | D1 |
| 2 Jan 1911 | Newcastle United | H | L | 1-5 | (1-0) | First Division | D1 |
| 7 Jan 1911 | Preston North End | A | W | 2-0 | (0-0) | First Division | D1 |
| 14 Jan 1911 | Crystal Palace | A | W | 4-0 | (2-0) | FA Cup | FAC |
| 21 Jan 1911 | Notts County | H | W | 5-0 | (4-0) | First Division | D1 |
| 28 Jan 1911 | Manchester United | A | D | 2-2 | (2-0) | First Division | D1 |
| 4 Feb 1911 | Liverpool | H | W | 2-1 | (0-1) | FA Cup | FAC |
| 11 Feb 1911 | Bury | A | D | 0-0 | (0-0) | First Division | D1 |
| 18 Feb 1911 | Sheffield United | H | W | 1-0 | (1-0) | First Division | D1 |
| 25 Feb 1911 | Derby County | A | L | 0-5 | (0-3) | FA Cup | FAC |
| 4 Mar 1911 | Sunderland | H | D | 2-2 | (2-1) | First Division | D1 |
| 11 Mar 1911 | Woolwich Arsenal | A | L | 0-1 | (0-1) | First Division | D1 |
| 18 Mar 1911 | Bradford City | H | D | 0-0 | (0-0) | First Division | D1 |
| 27 Mar 1911 | Aston Villa | A | L | 1-2 | (1-0) | First Division | D1 |
| 6 Apr 1911 | Blackburn Rovers | A | W | 1-0 | (0-0) | First Division | D1 |
| 8 Apr 1911 | Manchester City | A | L | 1-2 | (1-2) | First Division | D1 |
| 14 Apr 1911 | Nottingham Forest | H | W | 2-1 | (1-1) | First Division | D1 |
| 15 Apr 1911 | Oldham Athletic | A | L | 0-2 | (0-1) | First Division | D1 |
| 17 Apr 1911 | Tottenham Hotspur | A | W | 1-0 | (1-0) | First Division | D1 |
| 22 Apr 1911 | The Wednesday | H | D | 1-1 | (1-0) | First Division | D1 |
| 29 Apr 1911 | Bristol City | A | W | 1-0 | (1-0) | First Division | D1 |