If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 14 Aug 2021 | Southampton | H | W | 3-1 | (0-1) | Premier League | PL |
| 21 Aug 2021 | Leeds United | A | D | 2-2 | (1-1) | Premier League | PL |
| 24 Aug 2021 | Huddersfield Town | A | W | 2-1 | (1-1) | League Cup | LC |
| 28 Aug 2021 | Brighton & Hove Albion | A | W | 2-0 | (1-0) | Premier League | PL |
| 13 Sep 2021 | Burnley | H | W | 3-1 | (0-0) | Premier League | PL |
| 18 Sep 2021 | Aston Villa | A | L | 0-3 | (0-0) | Premier League | PL |
| 21 Sep 2021 | Queens Park Rangers | A | D | 2-2 | (1-2) | League Cup | LC |
| 25 Sep 2021 | Norwich City | H | W | 2-0 | (1-0) | Premier League | PL |
| 2 Oct 2021 | Manchester United | A | D | 1-1 | (0-1) | Premier League | PL |
| 17 Oct 2021 | West Ham United | H | L | 0-1 | (0-0) | Premier League | PL |
| 23 Oct 2021 | Watford | H | L | 2-5 | (1-1) | Premier League | PL |
| 1 Nov 2021 | Wolverhampton Wanderers | A | L | 1-2 | (0-2) | Premier League | PL |
| 7 Nov 2021 | Tottenham Hotspur | H | D | 0-0 | (0-0) | Premier League | PL |
| 21 Nov 2021 | Manchester City | A | L | 0-3 | (0-1) | Premier League | PL |
| 28 Nov 2021 | Brentford | A | L | 0-1 | (0-1) | Premier League | PL |
| 1 Dec 2021 | Liverpool | H | L | 1-4 | (1-2) | Premier League | PL |
| 6 Dec 2021 | Arsenal | H | W | 2-1 | (0-1) | Premier League | PL |
| 12 Dec 2021 | Crystal Palace | A | L | 1-3 | (0-1) | Premier League | PL |
| 16 Dec 2021 | Chelsea | A | D | 1-1 | (0-0) | Premier League | PL |
| 2 Jan 2022 | Brighton & Hove Albion | H | L | 2-3 | (0-2) | Premier League | PL |
| 8 Jan 2022 | Hull City | A | W | 3-2 | (2-1) | FA Cup | FAC |
| 15 Jan 2022 | Norwich City | A | L | 1-2 | (0-2) | Premier League | PL |
| 22 Jan 2022 | Aston Villa | H | L | 0-1 | (0-1) | Premier League | PL |
| 5 Feb 2022 | Brentford | H | W | 4-1 | (1-0) | FA Cup | FAC |
| 8 Feb 2022 | Newcastle United | A | L | 1-3 | (1-1) | Premier League | PL |
| 12 Feb 2022 | Leeds United | H | W | 3-0 | (2-0) | Premier League | PL |
| 19 Feb 2022 | Southampton | A | L | 0-2 | (0-0) | Premier League | PL |
| 26 Feb 2022 | Manchester City | H | L | 0-1 | (0-0) | Premier League | PL |
| 3 Mar 2022 | Boreham Wood | H | W | 2-0 | (0-0) | FA Cup | FAC |
| 7 Mar 2022 | Tottenham Hotspur | A | L | 0-5 | (0-3) | Premier League | PL |
| 13 Mar 2022 | Wolverhampton Wanderers | H | L | 0-1 | (0-0) | Premier League | PL |
| 17 Mar 2022 | Newcastle United | H | W | 1-0 | (0-0) | Premier League | PL |
| 20 Mar 2022 | Crystal Palace | A | L | 0-4 | (0-2) | FA Cup | FAC |
| 3 Apr 2022 | West Ham United | A | L | 1-2 | (0-1) | Premier League | PL |
| 6 Apr 2022 | Burnley | A | L | 2-3 | (2-1) | Premier League | PL |
| 9 Apr 2022 | Manchester United | H | W | 1-0 | (1-0) | Premier League | PL |
| 20 Apr 2022 | Leicester City | H | D | 1-1 | (0-1) | Premier League | PL |
| 24 Apr 2022 | Liverpool | A | L | 0-2 | (0-0) | Premier League | PL |
| 1 May 2022 | Chelsea | H | W | 1-0 | (0-0) | Premier League | PL |
| 8 May 2022 | Leicester City | A | W | 2-1 | (2-1) | Premier League | PL |
| 11 May 2022 | Watford | A | D | 0-0 | (0-0) | Premier League | PL |
| 15 May 2022 | Brentford | H | L | 2-3 | (2-1) | Premier League | PL |
| 19 May 2022 | Crystal Palace | H | W | 3-2 | (0-2) | Premier League | PL |
| 22 May 2022 | Arsenal | A | L | 1-5 | (1-2) | Premier League | PL |