If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 20 Aug 1960 | Tottenham Hotspur | A | L | 0-2 | (0-0) | First Division | D1 |
| 24 Aug 1960 | Manchester United | H | W | 4-0 | (1-0) | First Division | D1 |
| 27 Aug 1960 | Leicester City | H | W | 3-1 | (0-0) | First Division | D1 |
| 31 Aug 1960 | Manchester United | A | L | 0-4 | (0-3) | First Division | D1 |
| 3 Sep 1960 | Aston Villa | A | L | 2-3 | (1-3) | First Division | D1 |
| 5 Sep 1960 | Blackpool | A | W | 4-1 | (1-0) | First Division | D1 |
| 10 Sep 1960 | Wolverhampton Wanderers | H | W | 3-1 | (1-0) | First Division | D1 |
| 14 Sep 1960 | Blackpool | H | W | 1-0 | (0-0) | First Division | D1 |
| 17 Sep 1960 | Bolton Wanderers | A | W | 4-3 | (3-1) | First Division | D1 |
| 24 Sep 1960 | West Ham United | H | W | 4-1 | (2-1) | First Division | D1 |
| 1 Oct 1960 | Chelsea | A | D | 3-3 | (2-2) | First Division | D1 |
| 8 Oct 1960 | Preston North End | H | D | 0-0 | (0-0) | First Division | D1 |
| 12 Oct 1960 | Accrington Stanley (1891) | H | W | 3-1 | (2-0) | League Cup | LC |
| 15 Oct 1960 | Fulham | A | W | 3-2 | (1-2) | First Division | D1 |
| 24 Oct 1960 | Manchester City | H | W | 4-2 | (1-0) | First Division | D1 |
| 29 Oct 1960 | Nottingham Forest | A | W | 2-1 | (1-1) | First Division | D1 |
| 31 Oct 1960 | Walsall | H | W | 3-1 | (1-1) | League Cup | LC |
| 5 Nov 1960 | West Bromwich Albion | H | D | 1-1 | (1-1) | First Division | D1 |
| 12 Nov 1960 | Cardiff City | A | D | 1-1 | (1-1) | First Division | D1 |
| 19 Nov 1960 | Newcastle United | H | W | 5-0 | (1-0) | First Division | D1 |
| 23 Nov 1960 | Bury | H | W | 3-1 | (1-0) | League Cup | LC |
| 26 Nov 1960 | Arsenal | A | L | 2-3 | (0-3) | First Division | D1 |
| 3 Dec 1960 | Sheffield Wednesday | H | W | 4-2 | (1-2) | First Division | D1 |
| 10 Dec 1960 | Birmingham City | A | W | 4-2 | (1-1) | First Division | D1 |
| 17 Dec 1960 | Tottenham Hotspur | H | L | 1-3 | (0-2) | First Division | D1 |
| 21 Dec 1960 | Tranmere Rovers | A | W | 4-0 | (1-0) | League Cup | LC |
| 26 Dec 1960 | Burnley | A | W | 3-1 | (2-1) | First Division | D1 |
| 27 Dec 1960 | Burnley | H | L | 0-3 | (0-1) | First Division | D1 |
| 31 Dec 1960 | Leicester City | A | L | 1-4 | (0-3) | First Division | D1 |
| 7 Jan 1961 | Sheffield United | H | L | 0-1 | (0-1) | FA Cup | FAC |
| 21 Jan 1961 | Wolverhampton Wanderers | A | L | 1-4 | (1-2) | First Division | D1 |
| 4 Feb 1961 | Bolton Wanderers | H | L | 1-2 | (0-0) | First Division | D1 |
| 11 Feb 1961 | West Ham United | A | L | 0-4 | (0-1) | First Division | D1 |
| 15 Feb 1961 | Shrewsbury Town | A | L | 1-2 | (1-1) | League Cup | LC |
| 18 Feb 1961 | Chelsea | H | D | 1-1 | (1-1) | First Division | D1 |
| 25 Feb 1961 | Preston North End | A | L | 0-1 | (0-0) | First Division | D1 |
| 4 Mar 1961 | Fulham | H | W | 1-0 | (0-0) | First Division | D1 |
| 11 Mar 1961 | Manchester City | A | L | 1-2 | (0-1) | First Division | D1 |
| 18 Mar 1961 | Nottingham Forest | H | W | 1-0 | (1-0) | First Division | D1 |
| 22 Mar 1961 | Aston Villa | H | L | 1-2 | (1-0) | First Division | D1 |
| 25 Mar 1961 | West Bromwich Albion | A | L | 0-3 | (0-3) | First Division | D1 |
| 31 Mar 1961 | Blackburn Rovers | A | W | 3-1 | (2-0) | First Division | D1 |
| 1 Apr 1961 | Birmingham City | H | W | 1-0 | (0-0) | First Division | D1 |
| 3 Apr 1961 | Blackburn Rovers | H | D | 2-2 | (1-0) | First Division | D1 |
| 8 Apr 1961 | Newcastle United | A | W | 4-0 | (2-0) | First Division | D1 |
| 15 Apr 1961 | Cardiff City | H | W | 5-1 | (3-0) | First Division | D1 |
| 22 Apr 1961 | Sheffield Wednesday | A | W | 2-1 | (1-1) | First Division | D1 |
| 29 Apr 1961 | Arsenal | H | W | 4-1 | (3-0) | First Division | D1 |