If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 21 Aug 1965 | Northampton Town | H | W | 5-2 | (1-1) | First Division | D1 |
| 25 Aug 1965 | Sheffield Wednesday | A | L | 1-3 | (1-0) | First Division | D1 |
| 28 Aug 1965 | Stoke City | A | D | 1-1 | (0-1) | First Division | D1 |
| 31 Aug 1965 | Sheffield Wednesday | H | W | 5-1 | (3-0) | First Division | D1 |
| 4 Sep 1965 | Burnley | H | W | 1-0 | (0-0) | First Division | D1 |
| 7 Sep 1965 | West Bromwich Albion | H | L | 2-3 | (2-1) | First Division | D1 |
| 11 Sep 1965 | Chelsea | A | L | 1-3 | (1-2) | First Division | D1 |
| 15 Sep 1965 | West Bromwich Albion | A | D | 1-1 | (0-0) | First Division | D1 |
| 18 Sep 1965 | Arsenal | H | W | 3-1 | (2-0) | First Division | D1 |
| 25 Sep 1965 | Liverpool | A | L | 0-5 | (0-1) | First Division | D1 |
| 28 Sep 1965 | Nurnberg | A | D | 1-1 | (0-1) | Inter-Cities Fairs Cup | ICFC |
| 5 Oct 1965 | Blackburn Rovers | H | D | 2-2 | (1-2) | First Division | D1 |
| 9 Oct 1965 | Tottenham Hotspur | H | W | 3-1 | (2-0) | First Division | D1 |
| 12 Oct 1965 | Nurnberg | H | W | 1-0 | (0-0) | Inter-Cities Fairs Cup | ICFC |
| 16 Oct 1965 | Fulham | A | L | 2-3 | (1-2) | First Division | D1 |
| 23 Oct 1965 | Blackpool | H | D | 0-0 | (0-0) | First Division | D1 |
| 30 Oct 1965 | Blackburn Rovers | A | W | 2-1 | (2-1) | First Division | D1 |
| 3 Nov 1965 | Ujpest | A | L | 0-3 | (0-2) | Inter-Cities Fairs Cup | ICFC |
| 6 Nov 1965 | Leicester City | H | L | 1-2 | (0-1) | First Division | D1 |
| 13 Nov 1965 | Sheffield United | A | L | 0-2 | (0-1) | First Division | D1 |
| 16 Nov 1965 | Ujpest | H | W | 2-1 | (1-1) | Inter-Cities Fairs Cup | ICFC |
| 20 Nov 1965 | Leeds United | H | D | 0-0 | (0-0) | First Division | D1 |
| 27 Nov 1965 | West Ham United | A | L | 0-3 | (0-1) | First Division | D1 |
| 4 Dec 1965 | Sunderland | H | W | 2-0 | (0-0) | First Division | D1 |
| 11 Dec 1965 | Aston Villa | A | L | 2-3 | (0-3) | First Division | D1 |
| 15 Dec 1965 | Manchester United | A | L | 0-3 | (0-1) | First Division | D1 |
| 18 Dec 1965 | Fulham | H | W | 2-0 | (2-0) | First Division | D1 |
| 27 Dec 1965 | Nottingham Forest | A | L | 0-1 | (0-1) | First Division | D1 |
| 1 Jan 1966 | Tottenham Hotspur | A | D | 2-2 | (1-1) | First Division | D1 |
| 8 Jan 1966 | Aston Villa | H | W | 2-0 | (1-0) | First Division | D1 |
| 11 Jan 1966 | West Ham United | H | D | 2-2 | (0-1) | First Division | D1 |
| 15 Jan 1966 | Blackpool | A | L | 0-2 | (0-0) | First Division | D1 |
| 22 Jan 1966 | Sunderland | H | W | 3-0 | (1-0) | FA Cup | FAC |
| 29 Jan 1966 | Northampton Town | A | W | 2-0 | (2-0) | First Division | D1 |
| 5 Feb 1966 | Stoke City | H | W | 2-1 | (2-0) | First Division | D1 |
| 12 Feb 1966 | Bedford Town | A | W | 3-0 | (2-0) | FA Cup | FAC |
| 19 Feb 1966 | Burnley | A | D | 1-1 | (0-0) | First Division | D1 |
| 26 Feb 1966 | Chelsea | H | W | 2-1 | (1-0) | First Division | D1 |
| 5 Mar 1966 | Coventry City | H | W | 3-0 | (1-0) | FA Cup | FAC |
| 12 Mar 1966 | Arsenal | A | W | 1-0 | (1-0) | First Division | D1 |
| 15 Mar 1966 | Nottingham Forest | H | W | 3-0 | (0-0) | First Division | D1 |
| 19 Mar 1966 | Liverpool | H | D | 0-0 | (0-0) | First Division | D1 |
| 26 Mar 1966 | Manchester City | A | D | 0-0 | (0-0) | FA Cup | FAC |
| 29 Mar 1966 | Manchester City | H | D | 0-0 | (0-0) | FA Cup | FAC |
| 5 Apr 1966 | Manchester City | N | W | 2-0 | (2-0) | FA Cup | FAC |
| 8 Apr 1966 | Newcastle United | A | D | 0-0 | (0-0) | First Division | D1 |
| 9 Apr 1966 | Sheffield United | H | L | 1-3 | (0-2) | First Division | D1 |
| 11 Apr 1966 | Newcastle United | H | W | 1-0 | (0-0) | First Division | D1 |
| 16 Apr 1966 | Leeds United | A | L | 1-4 | (0-1) | First Division | D1 |
| 23 Apr 1966 | Manchester United | N | W | 1-0 | (0-0) | FA Cup | FAC |
| 25 Apr 1966 | Manchester United | H | D | 0-0 | (0-0) | First Division | D1 |
| 30 Apr 1966 | Sunderland | A | L | 0-2 | (0-1) | First Division | D1 |
| 4 May 1966 | Leicester City | A | L | 0-3 | (0-1) | First Division | D1 |
| 14 May 1966 | Sheffield Wednesday | N | W | 3-2 | (0-1) | FA Cup | FAC |