If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 16 Aug 1980 | Sunderland | A | L | 1-3 | (0-2) | First Division | D1 |
| 19 Aug 1980 | Leicester City | H | W | 1-0 | (1-0) | First Division | D1 |
| 23 Aug 1980 | Nottingham Forest | H | D | 0-0 | (0-0) | First Division | D1 |
| 26 Aug 1980 | Blackpool | H | W | 3-0 | (1-0) | League Cup | LC |
| 30 Aug 1980 | Ipswich Town | A | L | 0-4 | (0-2) | First Division | D1 |
| 3 Sep 1980 | Blackpool | A | D | 2-2 | (0-0) | League Cup | LC |
| 6 Sep 1980 | Wolverhampton Wanderers | H | W | 2-0 | (1-0) | First Division | D1 |
| 13 Sep 1980 | Aston Villa | A | W | 2-0 | (2-0) | First Division | D1 |
| 20 Sep 1980 | Crystal Palace | H | W | 5-0 | (0-0) | First Division | D1 |
| 24 Sep 1980 | West Bromwich Albion | H | L | 1-2 | (1-1) | League Cup | LC |
| 27 Sep 1980 | Coventry City | A | W | 5-0 | (3-0) | First Division | D1 |
| 4 Oct 1980 | Southampton | H | W | 2-1 | (1-1) | First Division | D1 |
| 7 Oct 1980 | Brighton & Hove Albion | A | W | 3-1 | (0-0) | First Division | D1 |
| 11 Oct 1980 | Leeds United | A | L | 0-1 | (0-0) | First Division | D1 |
| 18 Oct 1980 | Liverpool | H | D | 2-2 | (2-1) | First Division | D1 |
| 21 Oct 1980 | West Bromwich Albion | H | D | 1-1 | (1-1) | First Division | D1 |
| 25 Oct 1980 | Manchester United | A | L | 0-2 | (0-1) | First Division | D1 |
| 1 Nov 1980 | Tottenham Hotspur | H | D | 2-2 | (1-1) | First Division | D1 |
| 8 Nov 1980 | Norwich City | A | L | 1-2 | (0-0) | First Division | D1 |
| 12 Nov 1980 | Leicester City | A | W | 1-0 | (0-0) | First Division | D1 |
| 15 Nov 1980 | Sunderland | H | W | 2-1 | (1-1) | First Division | D1 |
| 22 Nov 1980 | Arsenal | A | L | 1-2 | (0-2) | First Division | D1 |
| 29 Nov 1980 | Birmingham City | H | D | 1-1 | (1-1) | First Division | D1 |
| 6 Dec 1980 | Stoke City | A | D | 2-2 | (1-1) | First Division | D1 |
| 13 Dec 1980 | Brighton & Hove Albion | H | W | 4-3 | (2-2) | First Division | D1 |
| 26 Dec 1980 | Manchester City | H | L | 0-2 | (0-0) | First Division | D1 |
| 27 Dec 1980 | Middlesbrough | A | L | 0-1 | (0-1) | First Division | D1 |
| 3 Jan 1981 | Arsenal | H | W | 2-0 | (0-0) | FA Cup | FAC |
| 10 Jan 1981 | Arsenal | H | L | 1-2 | (0-0) | First Division | D1 |
| 17 Jan 1981 | Ipswich Town | H | D | 0-0 | (0-0) | First Division | D1 |
| 24 Jan 1981 | Liverpool | H | W | 2-1 | (1-0) | FA Cup | FAC |
| 31 Jan 1981 | Nottingham Forest | A | L | 0-1 | (0-1) | First Division | D1 |
| 7 Feb 1981 | Aston Villa | H | L | 1-3 | (1-2) | First Division | D1 |
| 14 Feb 1981 | Southampton | A | D | 0-0 | (0-0) | FA Cup | FAC |
| 17 Feb 1981 | Southampton | H | W | 1-0 | (0-0) | FA Cup | FAC |
| 21 Feb 1981 | Coventry City | H | W | 3-0 | (1-0) | First Division | D1 |
| 28 Feb 1981 | Crystal Palace | A | W | 3-2 | (1-1) | First Division | D1 |
| 7 Mar 1981 | Manchester City | H | D | 2-2 | (1-1) | FA Cup | FAC |
| 11 Mar 1981 | Manchester City | A | L | 1-3 | (0-0) | FA Cup | FAC |
| 14 Mar 1981 | Leeds United | H | L | 1-2 | (1-0) | First Division | D1 |
| 17 Mar 1981 | Southampton | A | L | 0-3 | (0-1) | First Division | D1 |
| 21 Mar 1981 | Liverpool | A | L | 0-1 | (0-0) | First Division | D1 |
| 28 Mar 1981 | Manchester United | H | L | 0-1 | (0-1) | First Division | D1 |
| 31 Mar 1981 | West Bromwich Albion | A | L | 0-2 | (0-1) | First Division | D1 |
| 4 Apr 1981 | Tottenham Hotspur | A | D | 2-2 | (2-0) | First Division | D1 |
| 11 Apr 1981 | Norwich City | H | L | 0-2 | (0-1) | First Division | D1 |
| 18 Apr 1981 | Middlesbrough | H | W | 4-1 | (2-1) | First Division | D1 |
| 20 Apr 1981 | Manchester City | A | L | 1-3 | (0-0) | First Division | D1 |
| 25 Apr 1981 | Stoke City | H | L | 0-1 | (0-0) | First Division | D1 |
| 2 May 1981 | Birmingham City | A | D | 1-1 | (1-1) | First Division | D1 |
| 4 May 1981 | Wolverhampton Wanderers | A | D | 0-0 | (0-0) | First Division | D1 |