If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 9 Aug 2005 | Villarreal | H | L | 1-2 | (1-2) | Champions League | CL |
| 13 Aug 2005 | Manchester United | H | L | 0-2 | (0-1) | Premier League | PL |
| 21 Aug 2005 | Bolton Wanderers | A | W | 1-0 | (0-0) | Premier League | PL |
| 24 Aug 2005 | Villarreal | A | L | 1-2 | (0-1) | Champions League | CL |
| 27 Aug 2005 | Fulham | A | L | 0-1 | (0-0) | Premier League | PL |
| 10 Sep 2005 | Portsmouth | H | L | 0-1 | (0-0) | Premier League | PL |
| 15 Sep 2005 | Dinamo Bucharest | A | L | 1-5 | (1-1) | UEFA Cup | UEFAC |
| 19 Sep 2005 | Arsenal | A | L | 0-2 | (0-2) | Premier League | PL |
| 24 Sep 2005 | Wigan Athletic | H | L | 0-1 | (0-0) | Premier League | PL |
| 29 Sep 2005 | Dinamo Bucharest | H | W | 1-0 | (1-0) | UEFA Cup | UEFAC |
| 2 Oct 2005 | Manchester City | A | L | 0-2 | (0-0) | Premier League | PL |
| 15 Oct 2005 | Tottenham Hotspur | A | L | 0-2 | (0-0) | Premier League | PL |
| 23 Oct 2005 | Chelsea | H | D | 1-1 | (1-0) | Premier League | PL |
| 26 Oct 2005 | Middlesbrough | H | L | 0-1 | (0-1) | League Cup | LC |
| 29 Oct 2005 | Birmingham City | A | W | 1-0 | (1-0) | Premier League | PL |
| 6 Nov 2005 | Middlesbrough | H | W | 1-0 | (1-0) | Premier League | PL |
| 19 Nov 2005 | West Bromwich Albion | A | L | 0-4 | (0-1) | Premier League | PL |
| 27 Nov 2005 | Newcastle United | H | W | 1-0 | (0-0) | Premier League | PL |
| 3 Dec 2005 | Blackburn Rovers | A | W | 2-0 | (2-0) | Premier League | PL |
| 11 Dec 2005 | Manchester United | A | D | 1-1 | (1-1) | Premier League | PL |
| 14 Dec 2005 | West Ham United | H | L | 1-2 | (1-1) | Premier League | PL |
| 17 Dec 2005 | Bolton Wanderers | H | L | 0-4 | (0-1) | Premier League | PL |
| 26 Dec 2005 | Aston Villa | A | L | 0-4 | (0-1) | Premier League | PL |
| 28 Dec 2005 | Liverpool | H | L | 1-3 | (1-2) | Premier League | PL |
| 31 Dec 2005 | Sunderland | A | W | 1-0 | (0-0) | Premier League | PL |
| 2 Jan 2006 | Charlton Athletic | H | W | 3-1 | (2-1) | Premier League | PL |
| 7 Jan 2006 | Millwall | A | D | 1-1 | (0-1) | FA Cup | FAC |
| 14 Jan 2006 | Portsmouth | A | W | 1-0 | (1-0) | Premier League | PL |
| 18 Jan 2006 | Millwall | H | W | 1-0 | (0-0) | FA Cup | FAC |
| 21 Jan 2006 | Arsenal | H | W | 1-0 | (1-0) | Premier League | PL |
| 28 Jan 2006 | Chelsea | H | D | 1-1 | (1-0) | FA Cup | FAC |
| 31 Jan 2006 | Wigan Athletic | A | D | 1-1 | (1-1) | Premier League | PL |
| 4 Feb 2006 | Manchester City | H | W | 1-0 | (1-0) | Premier League | PL |
| 8 Feb 2006 | Chelsea | A | L | 1-4 | (0-3) | FA Cup | FAC |
| 11 Feb 2006 | Blackburn Rovers | H | W | 1-0 | (1-0) | Premier League | PL |
| 25 Feb 2006 | Newcastle United | A | L | 0-2 | (0-0) | Premier League | PL |
| 4 Mar 2006 | West Ham United | A | D | 2-2 | (1-2) | Premier League | PL |
| 11 Mar 2006 | Fulham | H | W | 3-1 | (2-0) | Premier League | PL |
| 18 Mar 2006 | Aston Villa | H | W | 4-1 | (3-0) | Premier League | PL |
| 25 Mar 2006 | Liverpool | A | L | 1-3 | (0-1) | Premier League | PL |
| 1 Apr 2006 | Sunderland | H | D | 2-2 | (2-1) | Premier League | PL |
| 8 Apr 2006 | Charlton Athletic | A | D | 0-0 | (0-0) | Premier League | PL |
| 15 Apr 2006 | Tottenham Hotspur | H | L | 0-1 | (0-1) | Premier League | PL |
| 17 Apr 2006 | Chelsea | A | L | 0-3 | (0-1) | Premier League | PL |
| 22 Apr 2006 | Birmingham City | H | D | 0-0 | (0-0) | Premier League | PL |
| 29 Apr 2006 | Middlesbrough | A | W | 1-0 | (0-0) | Premier League | PL |
| 7 May 2006 | West Bromwich Albion | H | D | 2-2 | (0-1) | Premier League | PL |