If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 13 Sep 2020 | Tottenham Hotspur | A | W | 1-0 | (0-0) | Premier League | PL |
| 16 Sep 2020 | Salford City | H | W | 3-0 | (1-0) | League Cup | LC |
| 19 Sep 2020 | West Bromwich Albion | H | W | 5-2 | (2-1) | Premier League | PL |
| 23 Sep 2020 | Fleetwood Town | A | W | 5-2 | (2-0) | League Cup | LC |
| 26 Sep 2020 | Crystal Palace | A | W | 2-1 | (2-1) | Premier League | PL |
| 30 Sep 2020 | West Ham United | H | W | 4-1 | (1-0) | League Cup | LC |
| 3 Oct 2020 | Brighton & Hove Albion | H | W | 4-2 | (2-1) | Premier League | PL |
| 17 Oct 2020 | Liverpool | H | D | 2-2 | (1-1) | Premier League | PL |
| 25 Oct 2020 | Southampton | A | L | 0-2 | (0-2) | Premier League | PL |
| 1 Nov 2020 | Newcastle United | A | L | 1-2 | (0-0) | Premier League | PL |
| 7 Nov 2020 | Manchester United | H | L | 1-3 | (1-2) | Premier League | PL |
| 22 Nov 2020 | Fulham | A | W | 3-2 | (3-1) | Premier League | PL |
| 28 Nov 2020 | Leeds United | H | L | 0-1 | (0-0) | Premier League | PL |
| 5 Dec 2020 | Burnley | A | D | 1-1 | (1-1) | Premier League | PL |
| 12 Dec 2020 | Chelsea | H | W | 1-0 | (1-0) | Premier League | PL |
| 16 Dec 2020 | Leicester City | A | W | 2-0 | (1-0) | Premier League | PL |
| 19 Dec 2020 | Arsenal | H | W | 2-1 | (2-1) | Premier League | PL |
| 23 Dec 2020 | Manchester United | H | L | 0-2 | (0-0) | League Cup | LC |
| 26 Dec 2020 | Sheffield United | A | W | 1-0 | (0-0) | Premier League | PL |
| 1 Jan 2021 | West Ham United | H | L | 0-1 | (0-0) | Premier League | PL |
| 9 Jan 2021 | Rotherham United | H | W | 2-1 | (1-0) | FA Cup | FAC |
| 12 Jan 2021 | Wolverhampton Wanderers | A | W | 2-1 | (1-1) | Premier League | PL |
| 24 Jan 2021 | Sheffield Wednesday | H | W | 3-0 | (1-0) | FA Cup | FAC |
| 27 Jan 2021 | Leicester City | H | D | 1-1 | (1-0) | Premier League | PL |
| 30 Jan 2021 | Newcastle United | H | L | 0-2 | (0-0) | Premier League | PL |
| 3 Feb 2021 | Leeds United | A | W | 2-1 | (2-0) | Premier League | PL |
| 6 Feb 2021 | Manchester United | A | D | 3-3 | (0-2) | Premier League | PL |
| 10 Feb 2021 | Tottenham Hotspur | H | W | 5-4 | (3-2) | FA Cup | FAC |
| 14 Feb 2021 | Fulham | H | L | 0-2 | (0-0) | Premier League | PL |
| 17 Feb 2021 | Manchester City | H | L | 1-3 | (1-1) | Premier League | PL |
| 20 Feb 2021 | Liverpool | A | W | 2-0 | (1-0) | Premier League | PL |
| 1 Mar 2021 | Southampton | H | W | 1-0 | (1-0) | Premier League | PL |
| 4 Mar 2021 | West Bromwich Albion | A | W | 1-0 | (0-0) | Premier League | PL |
| 8 Mar 2021 | Chelsea | A | L | 0-2 | (0-1) | Premier League | PL |
| 13 Mar 2021 | Burnley | H | L | 1-2 | (1-2) | Premier League | PL |
| 20 Mar 2021 | Manchester City | H | L | 0-2 | (0-0) | FA Cup | FAC |
| 5 Apr 2021 | Crystal Palace | H | D | 1-1 | (0-0) | Premier League | PL |
| 12 Apr 2021 | Brighton & Hove Albion | A | D | 0-0 | (0-0) | Premier League | PL |
| 16 Apr 2021 | Tottenham Hotspur | H | D | 2-2 | (1-1) | Premier League | PL |
| 23 Apr 2021 | Arsenal | A | W | 1-0 | (0-0) | Premier League | PL |
| 1 May 2021 | Aston Villa | H | L | 1-2 | (1-1) | Premier League | PL |
| 9 May 2021 | West Ham United | A | W | 1-0 | (1-0) | Premier League | PL |
| 13 May 2021 | Aston Villa | A | D | 0-0 | (0-0) | Premier League | PL |
| 16 May 2021 | Sheffield United | H | L | 0-1 | (0-1) | Premier League | PL |
| 19 May 2021 | Wolverhampton Wanderers | H | W | 1-0 | (0-0) | Premier League | PL |
| 23 May 2021 | Manchester City | A | L | 0-5 | (0-2) | Premier League | PL |