If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 1 Sep 1900 | Preston North End | A | W | 2-1 | (1-1) | First Division | D1 |
| 8 Sep 1900 | Wolverhampton Wanderers | H | W | 5-1 | (3-0) | First Division | D1 |
| 15 Sep 1900 | Aston Villa | A | W | 2-1 | (1-0) | First Division | D1 |
| 22 Sep 1900 | Liverpool | H | D | 1-1 | (1-0) | First Division | D1 |
| 29 Sep 1900 | Newcastle United | A | L | 0-1 | (0-1) | First Division | D1 |
| 6 Oct 1900 | Sheffield United | H | W | 3-1 | (0-1) | First Division | D1 |
| 13 Oct 1900 | Manchester City | A | L | 0-1 | (0-1) | First Division | D1 |
| 27 Oct 1900 | Nottingham Forest | A | L | 1-2 | (0-1) | First Division | D1 |
| 3 Nov 1900 | Blackburn Rovers | H | D | 0-0 | (0-0) | First Division | D1 |
| 10 Nov 1900 | Stoke | A | W | 2-0 | (0-0) | First Division | D1 |
| 17 Nov 1900 | West Bromwich Albion | H | W | 1-0 | (1-0) | First Division | D1 |
| 24 Nov 1900 | The Wednesday | H | D | 1-1 | (1-1) | First Division | D1 |
| 1 Dec 1900 | Sunderland | A | L | 0-2 | (0-1) | First Division | D1 |
| 8 Dec 1900 | Derby County | H | W | 2-0 | (0-0) | First Division | D1 |
| 15 Dec 1900 | Bolton Wanderers | A | L | 0-1 | (0-0) | First Division | D1 |
| 22 Dec 1900 | Notts County | H | L | 0-1 | (0-1) | First Division | D1 |
| 25 Dec 1900 | Sheffield United | A | L | 1-2 | (1-1) | First Division | D1 |
| 26 Dec 1900 | Bury | H | D | 3-3 | (1-3) | First Division | D1 |
| 29 Dec 1900 | Preston North End | H | W | 4-1 | (2-0) | First Division | D1 |
| 1 Jan 1901 | Bury | A | L | 0-3 | (0-1) | First Division | D1 |
| 5 Jan 1901 | Wolverhampton Wanderers | A | D | 1-1 | (0-0) | First Division | D1 |
| 12 Jan 1901 | Aston Villa | H | W | 2-1 | (2-1) | First Division | D1 |
| 19 Jan 1901 | Liverpool | A | W | 2-1 | (1-1) | First Division | D1 |
| 9 Feb 1901 | Southampton | A | W | 3-1 | (0-1) | FA Cup | FAC |
| 16 Feb 1901 | Manchester City | H | W | 5-2 | (3-0) | First Division | D1 |
| 23 Feb 1901 | Sheffield United | A | L | 0-2 | (0-1) | FA Cup | FAC |
| 2 Mar 1901 | Nottingham Forest | H | W | 4-1 | (3-1) | First Division | D1 |
| 9 Mar 1901 | Blackburn Rovers | A | L | 1-2 | (0-1) | First Division | D1 |
| 16 Mar 1901 | Stoke | H | W | 3-0 | (3-0) | First Division | D1 |
| 30 Mar 1901 | The Wednesday | A | L | 1-3 | (0-1) | First Division | D1 |
| 6 Apr 1901 | Sunderland | H | W | 1-0 | (1-0) | First Division | D1 |
| 8 Apr 1901 | Newcastle United | H | L | 0-1 | (0-1) | First Division | D1 |
| 9 Apr 1901 | Notts County | A | L | 2-3 | (1-2) | First Division | D1 |
| 13 Apr 1901 | Derby County | A | W | 1-0 | (1-0) | First Division | D1 |
| 20 Apr 1901 | Bolton Wanderers | H | L | 2-3 | (1-2) | First Division | D1 |
| 22 Apr 1901 | West Bromwich Albion | A | W | 2-1 | (1-0) | First Division | D1 |