If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 15 Aug 2009 | Arsenal | H | L | 1-6 | (0-3) | Premier League | PL |
| 20 Aug 2009 | Sigma Olomouc | H | W | 4-0 | (2-0) | Europa League | EL |
| 23 Aug 2009 | Burnley | A | L | 0-1 | (0-1) | Premier League | PL |
| 27 Aug 2009 | Sigma Olomouc | A | D | 1-1 | (1-0) | Europa League | EL |
| 30 Aug 2009 | Wigan Athletic | H | W | 2-1 | (0-0) | Premier League | PL |
| 13 Sep 2009 | Fulham | A | L | 1-2 | (1-0) | Premier League | PL |
| 17 Sep 2009 | AEK Athens | H | W | 4-0 | (3-0) | Europa League | EL |
| 20 Sep 2009 | Blackburn Rovers | H | W | 3-0 | (1-0) | Premier League | PL |
| 23 Sep 2009 | Hull City | A | W | 4-0 | (3-0) | League Cup | LC |
| 26 Sep 2009 | Portsmouth | A | W | 1-0 | (1-0) | Premier League | PL |
| 1 Oct 2009 | BATE Borisov | A | W | 2-1 | (0-1) | Europa League | EL |
| 4 Oct 2009 | Stoke City | H | D | 1-1 | (0-0) | Premier League | PL |
| 17 Oct 2009 | Wolverhampton Wanderers | H | D | 1-1 | (0-0) | Premier League | PL |
| 22 Oct 2009 | Benfica | A | L | 0-5 | (0-1) | Europa League | EL |
| 25 Oct 2009 | Bolton Wanderers | A | L | 2-3 | (1-2) | Premier League | PL |
| 27 Oct 2009 | Tottenham Hotspur | A | L | 0-2 | (0-1) | League Cup | LC |
| 31 Oct 2009 | Aston Villa | H | D | 1-1 | (1-0) | Premier League | PL |
| 5 Nov 2009 | Benfica | H | L | 0-2 | (0-0) | Europa League | EL |
| 8 Nov 2009 | West Ham United | A | W | 2-1 | (1-0) | Premier League | PL |
| 21 Nov 2009 | Manchester United | A | L | 0-3 | (0-1) | Premier League | PL |
| 25 Nov 2009 | Hull City | A | L | 2-3 | (0-3) | Premier League | PL |
| 29 Nov 2009 | Liverpool | H | L | 0-2 | (0-1) | Premier League | PL |
| 2 Dec 2009 | AEK Athens | A | W | 1-0 | (1-0) | Europa League | EL |
| 6 Dec 2009 | Tottenham Hotspur | H | D | 2-2 | (0-0) | Premier League | PL |
| 12 Dec 2009 | Chelsea | A | D | 3-3 | (2-2) | Premier League | PL |
| 17 Dec 2009 | BATE Borisov | H | L | 0-1 | (0-0) | Europa League | EL |
| 20 Dec 2009 | Birmingham City | H | D | 1-1 | (1-1) | Premier League | PL |
| 26 Dec 2009 | Sunderland | A | D | 1-1 | (0-1) | Premier League | PL |
| 28 Dec 2009 | Burnley | H | W | 2-0 | (0-0) | Premier League | PL |
| 2 Jan 2010 | Carlisle United | H | W | 3-1 | (1-1) | FA Cup | FAC |
| 9 Jan 2010 | Arsenal | A | D | 2-2 | (1-1) | Premier League | PL |
| 16 Jan 2010 | Manchester City | H | W | 2-0 | (2-0) | Premier League | PL |
| 23 Jan 2010 | Birmingham City | H | L | 1-2 | (0-2) | FA Cup | FAC |
| 27 Jan 2010 | Sunderland | H | W | 2-0 | (2-0) | Premier League | PL |
| 30 Jan 2010 | Wigan Athletic | A | W | 1-0 | (0-0) | Premier League | PL |
| 6 Feb 2010 | Liverpool | A | L | 0-1 | (0-0) | Premier League | PL |
| 10 Feb 2010 | Chelsea | H | W | 2-1 | (1-1) | Premier League | PL |
| 16 Feb 2010 | Sporting Lisbon | H | W | 2-1 | (1-0) | Europa League | EL |
| 20 Feb 2010 | Manchester United | H | W | 3-1 | (1-1) | Premier League | PL |
| 25 Feb 2010 | Sporting Lisbon | A | L | 0-3 | (0-0) | Europa League | EL |
| 28 Feb 2010 | Tottenham Hotspur | A | L | 1-2 | (0-2) | Premier League | PL |
| 7 Mar 2010 | Hull City | H | W | 5-1 | (2-1) | Premier League | PL |
| 13 Mar 2010 | Birmingham City | A | D | 2-2 | (2-1) | Premier League | PL |
| 20 Mar 2010 | Bolton Wanderers | H | W | 2-0 | (0-0) | Premier League | PL |
| 24 Mar 2010 | Manchester City | A | W | 2-0 | (1-0) | Premier League | PL |
| 27 Mar 2010 | Wolverhampton Wanderers | A | D | 0-0 | (0-0) | Premier League | PL |
| 4 Apr 2010 | West Ham United | H | D | 2-2 | (1-0) | Premier League | PL |
| 14 Apr 2010 | Aston Villa | A | D | 2-2 | (1-0) | Premier League | PL |
| 17 Apr 2010 | Blackburn Rovers | A | W | 3-2 | (1-0) | Premier League | PL |
| 25 Apr 2010 | Fulham | H | W | 2-1 | (0-1) | Premier League | PL |
| 1 May 2010 | Stoke City | A | D | 0-0 | (0-0) | Premier League | PL |
| 9 May 2010 | Portsmouth | H | W | 1-0 | (0-0) | Premier League | PL |