If you want to find out the scorers, line-ups and more details on the game, click on the full-time score.
| Date | Opponents | V | Res | HT | Competition | Comp | |
|---|---|---|---|---|---|---|---|
| 14 Aug 2010 | Blackburn Rovers | A | L | 0-1 | (0-1) | Premier League | PL |
| 21 Aug 2010 | Wolverhampton Wanderers | H | D | 1-1 | (1-0) | Premier League | PL |
| 25 Aug 2010 | Huddersfield Town | H | W | 5-1 | (2-1) | League Cup | LC |
| 29 Aug 2010 | Aston Villa | A | L | 0-1 | (0-1) | Premier League | PL |
| 11 Sep 2010 | Manchester United | H | D | 3-3 | (1-1) | Premier League | PL |
| 18 Sep 2010 | Newcastle United | H | L | 0-1 | (0-1) | Premier League | PL |
| 21 Sep 2010 | Brentford | A | D | 1-1 | (1-1) | League Cup | LC |
| 25 Sep 2010 | Fulham | A | D | 0-0 | (0-0) | Premier League | PL |
| 2 Oct 2010 | Birmingham City | A | W | 2-0 | (0-0) | Premier League | PL |
| 17 Oct 2010 | Liverpool | H | W | 2-0 | (1-0) | Premier League | PL |
| 23 Oct 2010 | Tottenham Hotspur | A | D | 1-1 | (1-1) | Premier League | PL |
| 30 Oct 2010 | Stoke City | H | W | 1-0 | (0-0) | Premier League | PL |
| 6 Nov 2010 | Blackpool | A | D | 2-2 | (1-1) | Premier League | PL |
| 10 Nov 2010 | Bolton Wanderers | H | D | 1-1 | (0-0) | Premier League | PL |
| 14 Nov 2010 | Arsenal | H | L | 1-2 | (0-1) | Premier League | PL |
| 22 Nov 2010 | Sunderland | A | D | 2-2 | (1-1) | Premier League | PL |
| 27 Nov 2010 | West Bromwich Albion | H | L | 1-4 | (1-2) | Premier League | PL |
| 4 Dec 2010 | Chelsea | A | D | 1-1 | (0-1) | Premier League | PL |
| 11 Dec 2010 | Wigan Athletic | H | D | 0-0 | (0-0) | Premier League | PL |
| 20 Dec 2010 | Manchester City | A | W | 2-1 | (2-0) | Premier League | PL |
| 28 Dec 2010 | West Ham United | A | D | 1-1 | (1-1) | Premier League | PL |
| 1 Jan 2011 | Stoke City | A | L | 0-2 | (0-1) | Premier League | PL |
| 5 Jan 2011 | Tottenham Hotspur | H | W | 2-1 | (1-1) | Premier League | PL |
| 8 Jan 2011 | Scunthorpe United | A | W | 5-1 | (2-0) | FA Cup | FAC |
| 16 Jan 2011 | Liverpool | A | D | 2-2 | (0-1) | Premier League | PL |
| 22 Jan 2011 | West Ham United | H | D | 2-2 | (0-1) | Premier League | PL |
| 29 Jan 2011 | Chelsea | H | D | 1-1 | (0-0) | FA Cup | FAC |
| 1 Feb 2011 | Arsenal | A | L | 1-2 | (1-0) | Premier League | PL |
| 5 Feb 2011 | Blackpool | H | W | 5-3 | (1-1) | Premier League | PL |
| 13 Feb 2011 | Bolton Wanderers | A | L | 0-2 | (0-1) | Premier League | PL |
| 19 Feb 2011 | Chelsea | A | D | 1-1 | (0-0) | FA Cup | FAC |
| 26 Feb 2011 | Sunderland | H | W | 2-0 | (2-0) | Premier League | PL |
| 1 Mar 2011 | Reading | H | L | 0-1 | (0-1) | FA Cup | FAC |
| 5 Mar 2011 | Newcastle United | A | W | 2-1 | (2-1) | Premier League | PL |
| 9 Mar 2011 | Birmingham City | H | D | 1-1 | (1-1) | Premier League | PL |
| 19 Mar 2011 | Fulham | H | W | 2-1 | (1-0) | Premier League | PL |
| 2 Apr 2011 | Aston Villa | H | D | 2-2 | (1-0) | Premier League | PL |
| 9 Apr 2011 | Wolverhampton Wanderers | A | W | 3-0 | (3-0) | Premier League | PL |
| 16 Apr 2011 | Blackburn Rovers | H | W | 2-0 | (0-0) | Premier League | PL |
| 23 Apr 2011 | Manchester United | A | L | 0-1 | (0-0) | Premier League | PL |
| 30 Apr 2011 | Wigan Athletic | A | D | 1-1 | (0-1) | Premier League | PL |
| 7 May 2011 | Manchester City | H | W | 2-1 | (0-1) | Premier League | PL |
| 14 May 2011 | West Bromwich Albion | A | L | 0-1 | (0-1) | Premier League | PL |
| 22 May 2011 | Chelsea | H | W | 1-0 | (0-0) | Premier League | PL |